Inclisiran (brand name is Leqvio) is a medication used to treat individuals with high cholesterol that hasn’t been effectively reduced by other treatments. It was approved for use on the NHS in 2021, following clinical trials that showed it can lower LDL cholesterol levels by approximately 50%. Inclisiran belongs to a new class of gene-silencing drugs. It works by ‘silencing’ the PCSK9 gene, thereby enhancing the liver’s ability to remove harmful cholesterol from the blood.
Why is Inclisiran Given?
Inclisiran is prescribed for patients who are unable to reach their cholesterol targets despite trying other treatments, including statins, either due to insufficient LDL reduction or adverse side effects. It is often used in individuals with existing cardiovascular diseases such as heart disease, strokes, or peripheral arterial disease, when other treatment options have failed to lower cholesterol levels adequately. High LDL cholesterol can lead to worsening atherosclerosis, increasing the risk of further cardiovascular events.
How is Inclisiran Given?
Inclisiran is administered by a healthcare professional via an injection under the skin, typically in the abdomen, upper arm, or thigh. The treatment regimen is as follows:
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- Initial Injection: Administered by a healthcare professional.
- Second Dose: Given three months after the first injection.
- Ongoing Treatment: Subsequent injections are administered every six months.
What Does Inclisiran Treatment Involve?
Before starting inclisiran, a blood test is conducted to determine baseline cholesterol levels and overall health, including liver function, kidney function, thyroid status, and diabetes status (HbA1c). A follow-up appointment three months after the initial injection includes another blood test to reassess the lipid profile and confirm that the treatment is effective and safe.
What Can I Expect from Inclisiran?
Inclisiran is known to effectively reduce LDL cholesterol, typically by 50%, with results often noticeable within 90 days. It is approved for use in the UK and recommended by NICE for certain patients.
What are the Risks Associated with Taking Inclisiran?
Inclisiran is generally considered safe, with a low incidence of side effects. Some individuals may experience mild to moderate reactions at the injection site, such as rash, pain, or redness. Although allergic reactions are possible, none have been reported to date.
It is important to note that inclisiran is not suitable for individuals who are pregnant or breastfeeding.
